2010MY Mercedes-Benz E-Class EPA Fuel Mileage Estimates
| Model | Drivetrain | City | Highway | Combined |
| E350 coupe | 7-spd Automatic | 17 | 26 | 20 |
| E350 cabriolet (2011MY) | 7-spd Automatic | 17 | 25 | 20 |
| E350 BlueTEC (2011MY) | 7-spd Automatic | 24 (est) | 33 (est) | |
| E350 sedan | 7-spd Automatic | 18 | 26 | 21 |
| E350 4MATIC sedan | 7-spd Automatic | 17 | 24 | 19 |
| E350 4MATIC wagon (2011MY) | 7-spd Automatic | 16 | 23 | 19 |
| E550 coupe | 7-spd Automatic | 15 | 23 | 18 |
| E550 cabriolet (2011MY) | 7-spd Automatic | 15 | 22 | 17 |
| E550 sedan | 7-spd Automatic | 16 | 24 | 18 |
| E550 4MATIC sedan | 7-spd Automatic | 15 | 23 | 18 |
| E63 AMG sedan | 7-spd MCT Auto | 13 | 20 | 15 |
