2010MY Mercedes-Benz M-Class EPA Fuel Mileage Estimates
| Model | Drivetrain | City | Highway | Combined |
| ML350 | 7-spd Automatic | 16 | 21 | 18 |
| ML350 4MATIC | 7-spd Automatic | 15 | 20 | 17 |
| ML350 BlueTEC 4MATIC | 7-spd Automatic | 18 | 25 | 21 |
| ML450 HYBRID 4MATIC | 7-spd Automatic | 21 (est.) | 24 (est.) | 22 (est.) |
| ML550 4MATIC | 7-spd Automatic | 13 | 18 | 15 |
| ML63 AMG 4MATIC | 7-spd Automatic | 10 | 14 | 12 |
